PD07
Product Specifications
UNSPSC Description
PD07 is an orally active AChE inhibitor (IC50: 0.29 μM for hAChE). PD07 also inhibits ChEs, BACE1 (IC50: 13.42 μM), and Aβ1–42 aggregation in in vitro. PD07 is an antioxidant, and shows DPPH inhibitory activity (IC50: 26.46 μM). PD07 improves memory and cognition in Scopolamine (HY-N0296)-induced amnesia rats. PD07 can be used for research of Alzheimer’s disease[1].
Target Antigen
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd07.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C(N2CCN(C(/C=C/C=C/C3=CC(OCO4)=C4C=C3)=O)CC2)=O)C=C1
Molecular Weight
424.88
References & Citations
[1]Bhanukiran K, et al. Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease. ACS Chem Neurosci. 2023 Aug 2;14(15):2743-2760.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149340/PD07-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149340/
Clinical Information
No Development Reported
Curated Selection
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