PD07
PD07 is an orally active AChE inhibitor (IC50: 0.29 μM for hAChE) . PD07 also inhibits ChEs, BACE1 (IC50: 13.42 μM), and Aβ1–42 aggregation in in vitro. PD07 is an antioxidant, and shows DPPH inhibitory activity (IC50: 26.46 μM) . PD07 improves memory and cognition in Scopolamine (HY-N0296) -induced amnesia rats. PD07 can be used for research of Alzheimer’s disease[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd07.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C(N2CCN(C(/C=C/C=C/C3=CC(OCO4)=C4C=C3)=O)CC2)=O)C=C1
Molecular Formula
C23H21ClN2O4
Molecular Weight
424.88
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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