BO-1

BO-1 is a benzoate ester with antibacterial activity. BO-1 inhibits multidrug-resistant Staphylococcus aureus, and acts function synergistically with antibiotic, such as Ciprofloxacin (HY-B0356) . BO-1 can reverse the resistance of antibiotic-resistant S. aureus strains, and decreases the level of inflammatory factors IL-6 and C-reactive protein in vivo in mice[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bo-1.html

Solubility

10 mM in DMSO

Smiles

O[C@]1(COC(C2=CC=CC=C2)=O)[C@H](Cl)C=C[C@@H](OC(C3=CC=CC=C3)=O)[C@@H]1O

Molecular Formula

C21H19ClO6

Molecular Weight

402.82

References & Citations

[1]Xiao CY, et al. Natural Product BO-1 as an Inner Responsive Molecule Inhibits Antimicrobial-Resistant Staphylococcus aureus via Synergism. ACS Infect Dis. 2023 Aug 11;9 (8) :1523-1533.