TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a KD value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases[1].
Product Specifications
CAS Number
2945197-77-1
UNSPSC
12352005
Target
Caspase; NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O
Molecular Formula
C24H26N2O5
Molecular Weight
422.47
References & Citations
[1]Yang Y, et al. Structure-Based Drug Design and Synthesis of Pyrrolidine-2,5-diones as Novel TNF-α Inhibitors. J Chem Inf Model. 2023 Jun 26;63 (12) :3911-3924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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