Pafuramidine (maleate)
Pafuramidine (maleate) (DB289 (maleate) ) is an orally active proagent of Furamidine. Pafuramidine (maleate) (DB289 (maleate) ) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria[1][2][3].
Product Specifications
CAS Number
837369-26-3
Product Name Alternative
DB289 (maleate)
UNSPSC
12352005
Target
Antibiotic; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pafuramidine-maleate.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C\C(O)=O)=O.N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(NOC)=N)C=C3)O2)C=C1)NOC
Molecular Formula
C24H24N4O7
Molecular Weight
480.47
References & Citations
[1]Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis (4-amidinophenyl) - furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53 (3) :953-7.|[2]Chen D, et al. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. Expert Rev Anti Infect Ther. 2007 Dec;5 (6) :921-8.|[3]Pohlig G, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS Negl Trop Dis. 2016 Feb 16;10 (2) :e0004363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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