Anticancer agent 131

HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC50 of 5.59 μM[1].

Product Specifications

CAS Number

2864443-47-8

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-131.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(O)C(C2=C(C3=CC=C([N+]([O-])=O)C=C3)C(N(C4=CC=CC=C4)C5=C2CN(C6=C(C)C=CC=C6C)C5=O)=O)=C1

Molecular Formula

C33H24ClN3O5

Molecular Weight

578.01

References & Citations

[1]An YN, et.al. Unexpected Cascade Sequence Forming the C (sp3) -N/C (sp2) -C (sp2) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity. J Org Chem. 2023 Jul 7;88 (13) :7998-8009.