MKA031

MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) -induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection[1].

Product Specifications

CAS Number

[2951012-00-1]

UNSPSC

12352005

Target

Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mka031.html

Purity

98.69

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=CC=C1)C2=CC=C(C=C2)N3N=NC(C(NCC4=CC=CS4)=O)=C3

Molecular Formula

C21H17N5O2S

Molecular Weight

403.46

References & Citations

[1]Chen D, et al. Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos. J Med Chem. 2023 Jul 13;66 (13) :8767-8781.