PSMA-IN-1
PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a Ki value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λEX: 620 nm; λEM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
PSMA
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/psma-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C1=O)=C(NC[C@H](NC(N[C@@H](CCCCNC(CCCCC[N+]2=C(C(C)(C3=C2C=CC=C3)C)/C=C4C([O-])=C(C\4=O)/C=C5C(C)(C6=C(N/5CCCCCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CNC(C7=O)=C(C7=O)O)=O)C(O)=O)=O)C=CC=C6)C)=O)C(O)=O)=O)C(O)=O)C1=O
Molecular Formula
C66H80N10O20
Molecular Weight
1333.40
References & Citations
[1]Wang X, et al. Design and Characterization of Squaramic Acid-Based Prostate-Specific Membrane Antigen Inhibitors for Prostate Cancer. J Med Chem. 2023 May 25;66 (10) :6889-6904.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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