JAK1-IN-12
JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. And IC50s of 0.423 μM, 0.410 μM and 1.12 μM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases[1].
Product Specifications
CAS Number
2945204-95-3
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-in-12.html
Solubility
10 mM in DMSO
Smiles
O[C@]12C[C@@H](C[C@H]3C2)[C@H](NC4=C(C=CN5)C5=NC=C4C6=CNN=C6)[C@@H](C3)C1
Molecular Formula
C20H23N5O
Molecular Weight
349.43
References & Citations
[1]Lang JJ, et al. Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. J Med Chem. 2023 May 25;66 (10) :6725-6742.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2
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