ATM Inhibitor-7

ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562) . ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1].

Product Specifications

CAS Number

[3033712-80-7]

UNSPSC

12352005

Target

Apoptosis; ATM/ATR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atm-inhibitor-7.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCCOC1=NC=C(C2=CC=C(N=CC3=C4N([C@H](C)C5=CC=CC=C5)N=N3)C4=C2)C=C1

Molecular Formula

C27H28N6O

Molecular Weight

452.55

References & Citations

[1]Shiyu Zhang, et al. Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors. ACS Med. Chem. Lett. 2023.