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DNMT-IN-3

DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium) . DNMT-IN-3 can be used for malaria related research[1].

Product Specifications

CAS Number

1683516-27-9

UNSPSC

12352005

Target

DNA Methyltransferase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dnmt-in-3.html

Solubility

10 mM in DMSO

Smiles

C1(NCCNC2=CC=CC3=C2C=CC=C3)=C4C=CC(OCC5CCN(CC5)CCNC6=C7C=CC=CC7=NC=C6)=CC4=NC=N1

Molecular Formula

C37H39N7O

Molecular Weight

597.75

References & Citations

[1]Dobrescu I, et.al. Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors. ACS Infect Dis. 2023 Jun 9; 9 (6) :1257-1266.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium

Frequently Asked Questions

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