FM04

FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM) . FM04 inhibits P-gp in 2 mechanism: (1) FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2) FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].

Product Specifications

CAS Number

[1807320-40-6]

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fm04.html

Purity

99.86

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=CC=C(OCCOCCNCC3=CC=CC=C3)C=C2)OC4=C1C=CC=C4

Molecular Formula

C26H25NO4

Molecular Weight

415.48

References & Citations

[1]Liu Z, et al. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04. J Med Chem. 2023 Apr 25.