HBChE-IN-1
HBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research[1].
Product Specifications
CAS Number
1776948-12-9
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hbche-in-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CCCCN1CCC[C@H]2CSCCCNC3=CC=C(C4=C3C(C5=CC=CC=C5S4)=O)C
Molecular Formula
C27H34N2OS2
Molecular Weight
466.70
References & Citations
[1]Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
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