Tau/Aβ40 aggregation-IN-1
Tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ40 aggregation inhibitor with IC50s of 1.8 μM and 1.3 μM, respectively[1].
Product Specifications
CAS Number
[2973377-10-3]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tau-aβ40-aggregation-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C2SC3=C(C(NCCC4CCN(CC4)C)=CC=C3C)C(C2=C1)=O
Molecular Formula
C23H28N2O2S
Molecular Weight
396.55
References & Citations
[1]Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
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