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Tau/Aβ40 aggregation-IN-1

Tau/Aβ40 aggregation-IN-1 (Compound 20) is a tau and Aβ40 aggregation inhibitor with IC50s of 1.8 μM and 1.3 μM, respectively[1].

Product Specifications

CAS Number

[2973377-10-3]

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tau-aβ40-aggregation-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C2SC3=C(C(NCCC4CCN(CC4)C)=CC=C3C)C(C2=C1)=O

Molecular Formula

C23H28N2O2S

Molecular Weight

396.55

References & Citations

[1]Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; BChE

Curated Selection

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