PTP1B/AKR1B1-IN-2
PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM) . PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM) [1].
Product Specifications
UNSPSC
12352005
Target
Aldose Reductase; Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ptp1b-akr1b1-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(CCN1C(/C(SC1=S)=C/C2=CC=CC(OCCCCC3=CC=CC=C3)=C2)=O)O
Molecular Formula
C23H23NO4S2
Molecular Weight
441.56
References & Citations
[1]Maccari R, et al. Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl) alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors. Eur J Med Chem. 2023 Apr 5;252:115270.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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