Aβ-IN-6
Product Specifications
UNSPSC Description
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1].
Target Antigen
Amyloid-β; Keap1-Nrf2
Type
Reference compound
Related Pathways
Neuronal Signaling;NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ-in-6.html
Solubility
10 mM in DMSO
Smiles
CCCCN1C=C(N=N1)C/C(C(/C=C/C2=CC=C(C=C2)OC)=O)=C(\C=C\C3=CC=C(C=C3)OC)O
Molecular Weight
473.56
References & Citations
[1]Ersilia De Lorenzi, et al. Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold. Eur J Med Chem. 2023 Apr 5;252:115297.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149246/Aβ-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149246/
Clinical Information
No Development Reported
Curated Selection
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