Keap1-Nrf2-IN-15
Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively[1].
Product Specifications
CAS Number
2456295-45-5
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-15.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)S(=O)(N(C2=CC(CCCN3C(C4=C(C3=O)C=CC=C4)=O)=C(C5=CC=CC=C52)N(S(=O)(C6=CC=C(C=C6)OC)=O)CC(O)=O)CC(O)=O)=O
Molecular Formula
C39H35N3O12S2
Molecular Weight
801.84
References & Citations
[1]Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis (arylsulfonamido) naphthalene-N, N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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