Topo II/HDAC-IN-2
Topo II/HDAC-IN-2 (8d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-2 (8d) induces apoptosis[1].
Product Specifications
CAS Number
[2922269-24-5]
UNSPSC
12352005
Target
Apoptosis; HDAC; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topo-ii-hdac-in-2.html
Solubility
10 mM in DMSO
Smiles
CCN1C(C2=C(C3=C(N2)C=CC=C3)N=C1SCCCCC(NO)=O)=O
Molecular Formula
C17H20N4O3S
Molecular Weight
360.43
References & Citations
[1]Mengmiao Zhao, et al. Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. Eur J Med Chem. 2023 Apr 5;252:115303.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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