HAChE-IN-2

HAChE-IN-2 is a potent hAChE inhibitor, with an IC50 of 0.71 μM. hAChE-IN-2 can also inhibits tau-oligomerization, with an EC50 of 2.21 μM. hAChE-IN-2 exhibits neuroprotective activity[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hache-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=CC(C(N2CCN(CC2)C3=CN=CC=N3)C4=CC=C(C=C4)F)=C1O

Molecular Formula

C22H23FN4O2

Molecular Weight

394.44

References & Citations

[1]Madhav H, et, al. Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. Eur J Med Chem. 2023 Jun 5;254:115354.