HAChE-IN-1
HAChE-IN-1 (Compound 24) is a potent hAChE inhibitor with an IC50 of 1.09 μM. hAChE-IN-1 inhibits tau-oligomerization with an EC50 of 2.71 μM in cellular tau FRET assay[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-1.html
Solubility
10 mM in DMSO
Smiles
OC(C=CC=C1)=C1C(N2CCN(CC2)C3=NC=CN=C3)C4=CC=C(C)C=C4
Molecular Formula
C22H24N4O
Molecular Weight
360.45
References & Citations
[1]Madhav H, et al. Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. Eur J Med Chem. 2023 Jun 5;254:115354.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Frequently Asked Questions
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