THR-β agonist 6

THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. THR-β agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-β agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research[1].

Product Specifications

CAS Number

[2791290-58-7]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/thr-β-agonist-6.html

Solubility

10 mM in DMSO

Smiles

CC(C)N1C(C=CC2=C1C=CN2C3=C(Cl)C=C(N4N=C(C#N)C(NC4=O)=O)C=C3Cl)=O

Molecular Formula

C20H14Cl2N6O3

Molecular Weight

457.27

References & Citations

[1]Liuyu Hu, et al. Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2023 Mar 9;66 (5) :3284-3300.