S1PR1 ligand 1

S1PR1 ligand 1 (compound 6 h) is a specific S1PR1 ligand with IC50 = 8.7 nM. S1PR1 ligand 1 has good brain uptake. S1PR1 ligand 1 can be labeled with 18F to study the function of S1PR1 in brain diseases[1].

Product Specifications

CAS Number

[2845249-11-6]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s1pr1-radioligand-1.html

Solubility

10 mM in DMSO

Smiles

CN(CC1=C(C=C(C=C1)C2=NOC(C3=CC(C(F)(F)F)=C(C=C3)OCCF)=N2)F)CCCO

Molecular Formula

C22H22F5N3O3

Molecular Weight

471.42

References & Citations

[1]Lin Qiu, et al. Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain. J Med Chem. 2023 Mar 16.