HPK1-IN-33
HPK1-IN-33 (compound 21) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a Ki value of 1.7 nM. HPK1-IN-33 inhibits the produce of IL-2 with EC50s of 286, >10000 nM in Jurkat WT and Jurkat HPK1 KO cells, respectively[1].
Product Specifications
CAS Number
2920000-86-6
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-33.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C2=C(NC3=NC=NC(N4CC[C@H]([C@H](C4)N)F)=C32)Cl)=CC=C1
Molecular Formula
C18H16ClFN6
Molecular Weight
370.81
References & Citations
[1]Gallego RA, et al. Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. J Med Chem. 2023 Mar 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1
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