Apricitabine
Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki=0.08 μM), as well as inhibits DNA polymerases α, β, and γ with Ki value of 300 μM, 12 μM, and 112.25 μM, respectively[1]. Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection[2].
Product Specifications
CAS Number
160707-69-7
Product Name Alternative
SPD754; AVX754
UNSPSC
12352005
Target
DNA/RNA Synthesis; HIV; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/apricitabine.html
Purity
99.8
Solubility
10 mM in DMSO
Smiles
O=C1N=C(N)C=CN1[C@@H]2S[C@H](CO)OC2
Molecular Formula
C8H11N3O3S
Molecular Weight
229.26
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
HIV-1
Frequently Asked Questions
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