SJ1461
Product Specifications
UNSPSC Description
SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj1461.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NC5=NN=CS5)=O
Molecular Weight
484.00
References & Citations
[1]Mladen Koravovic, et al. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur J Med Chem. 2023 May 5;251:115246.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149098/SJ1461-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149098/
Clinical Information
No Development Reported
CAS Number
2924546-70-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC215390L4V 200 µL
Syntenin (SDCBP) (NM_005625) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details