ITH12711

ITH12711 is a PP2A ligand. ITH12711 is able to cross the blood-brain barrier (BBB) . ITH12711 exerts neuroprotection via restoration of PP2A-phosphatase activity[1].

Product Specifications

CAS Number

[3042876-07-0]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ith12711.html

Solubility

10 mM in DMSO

Smiles

CC1(O[C@]2([H])[C@](CO1)([H])O[C@@H](C=C2)C[C@H](O)CO)C

Molecular Formula

C12H20O5

Molecular Weight

244.28

References & Citations

[1]Raquel L Arribas, et al. C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies. Eur J Med Chem. 2023 May 5;251:115245.