Anticancer agent 109
Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
Product Specifications
CAS Number
[2097497-16-8]
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-109.html
Solubility
10 mM in DMSO
Smiles
O=C(/C(C1=C2C)=C\C3=NC4=C(C=CC=C4)C=C3)NC1=NC(C)=C2O
Molecular Formula
C19H15N3O2
Molecular Weight
317.34
References & Citations
[1]Bae D, et al. Antitumor effect of 3- (quinolin-2-ylmethylene) -4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl
Curated Selection
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