AChE/BuChE/MAO-B-IN-2
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-buche-mao-b-in-2.html
Solubility
10 mM in DMSO
Smiles
CCN(C)C(OC1=CC=CC=C1C(/C=C/C2=CC=C(F)C=C2)=O)=O
Molecular Formula
C19H18FNO3
Molecular Weight
327.35
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MAO-B
Frequently Asked Questions
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