BPA-B9
BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (KD=39.29 ± 1.12 nM) . BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; PARP; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bpa-b9.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=CC(C2=CC(N3CCC(CC3)CO)=NC=C2)=C1)/C=C/C4=CC=CC=C4
Molecular Formula
C25H26N4O2
Molecular Weight
414.50
References & Citations
[1]Chen J, et al. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. Eur J Med Chem. 2023 Apr 6;254:115341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Mcl-1; PARP
Available Sizes
Frequently Asked Questions
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