Antiparasitic agent-15
Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Necroptosis; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antiparasitic-agent-15.html
Solubility
10 mM in DMSO
Smiles
CC1(S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C
Molecular Formula
C17H16N4OS
Molecular Weight
324.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Trypanosoma
Frequently Asked Questions
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