MR22
MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mr22.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F
Molecular Formula
C18H19F2N5O
Molecular Weight
359.37
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149075/MR22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149075/MR22-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[3027761-24-3]
Available Sizes
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