MR22

MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].

Product Specifications

CAS Number

[3027761-24-3]

UNSPSC

12352005

Target

Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mr22.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CNC1=NC=C2C=C(C(N(C2=N1)CCCCN)=O)C3=C(C=CC(F)=C3)F

Molecular Formula

C18H19F2N5O

Molecular Weight

359.37

References & Citations

[1]Marcel Rak, et al. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7 (8H) -one inhibitors towards the salt-inducible kinase (SIK) subfamily. European Journal of Medicinal Chemistry. Volume 254, 5 June 2023, 115347.