TSC24

TSC24, a thiosemicarbazone, is a potent cruzipain (CZP) inhibitor with an IC50 of 2.86 nM, a pIC50 of 8.54 and a pKa of 8.6. TSC24 has the potential for parasitic diseases research[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tsc24.html

Solubility

10 mM in DMSO

Smiles

NC(N/N=C(C1=CC=C(C(Cl)=C1)Cl)\CCN2CCCCC2)=S

Molecular Formula

C15H20Cl2N4S

Molecular Weight

359.32

References & Citations

[1]Gabriel Jasinski, et al. Design, synthesis and biological evaluation of novel thiosemicarbazones as cruzipain inhibitors. Eur J Med Chem. 2023 Apr 7;254:115345.