D-685
D-685, a prodrug of D-520, exhibits higher in vivo anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model than the parent D-520. D-685 reduces accumulation of human α-synuclein (α-syn) protein. D-685 exhibits facile brain penetration[1].
Product Specifications
CAS Number
2893801-00-6
UNSPSC
12352005
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-685.html
Solubility
10 mM in DMSO
Smiles
OC1=C2CC[C@H](N(CCN3CCN(C4=CC=C(C5=CC=C(OCO6)C6=C5)C=C4)CC3)CCC)CC2=CC=C1
Molecular Formula
C32H39N3O3
Molecular Weight
513.67
References & Citations
[1]Aloke K Dutta, et al. D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models. ACS Chem Neurosci. 2023 Mar 1;14 (5) :885-896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation
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