Viral polymerase-IN-1 (hydrochloride)

Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells[1].

Product Specifications

CAS Number

[2367587-02-6]

UNSPSC

12352005

Target

Influenza Virus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/viral-polymerase-in-1-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(NC(C3=NC=C(N)C=C3)=O)=NC2=O)O1.Cl

Molecular Formula

C15H16ClF2N5O5

Molecular Weight

419.77

References & Citations

[1]Hyeon-Min Cha, et al. Evaluation of Antiviral Activity of Gemcitabine Derivatives against Influenza Virus and Severe Acute Respiratory Syndrome Coronavirus 2. ACS Infect Dis. 2023 Apr 14;9 (4) :1033-1045.