DHODH-IN-22
Product Specifications
UNSPSC Description
DHODH-IN-22 is a potent, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 0.3 nM. DHODH-IN-22 can be used for researching acute myelogenous leukemia (AML)[1].
Target Antigen
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(F)=C(N2N=C(CO)N(CC)C2=O)N=C1O[C@@H](C)C(F)(F)F)NC3=C(Cl)C(OC)=NC=C3C
Molecular Weight
548.88
References & Citations
[1]Cisar JS, et al. N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J Med Chem. 2022 Aug 4.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149031/DHODH-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149031/
Clinical Information
No Development Reported
CAS Number
2450341-75-8
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