DHODH-IN-21
Product Specifications
UNSPSC Description
DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML)[1].
Target Antigen
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhodh-in-21.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C(F)C=C(C(NC3=C(Cl)N=CC=C3C)=O)C(O[C@@H](C)C(F)(F)F)=N2)N=C(N1CC)CO
Molecular Weight
518.85
References & Citations
[1]Justin S Cisar, et al. N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J Med Chem. 2022 Aug 4.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149030/DHODH-IN-21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149030/
Clinical Information
No Development Reported
CAS Number
2450341-39-4
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