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VEGFR-2-IN-23

VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].

Product Specifications

CAS Number

2411174-53-1

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-23.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N=C(C=C1C2=CC=C(C=C2)[N+]([O-])=O)C3=CC4=CC=CC=C4C=C3)NN

Molecular Formula

C22H15N5O2

Molecular Weight

381.39

References & Citations

[1]AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

Frequently Asked Questions

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