VEGFR-2-IN-23
VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase[1].
Product Specifications
CAS Number
2411174-53-1
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-23.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N=C(C=C1C2=CC=C(C=C2)[N+]([O-])=O)C3=CC4=CC=CC=C4C=C3)NN
Molecular Formula
C22H15N5O2
Molecular Weight
381.39
References & Citations
[1]AbdelHaleem A, et al. Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Oct;103:104222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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