Tubulin polymerization-IN-26

Tubulin polymerization-IN-26 (compound 12h) can inhibit the polymerization of microtubulin by binding to the colchicine binding site of microtubulin with an IC50 value of 4.64 μM. Tubulin polymerization-IN-26 can induce apoptosis and inhibit cell metastasis or migration, and can be used as a potential compound for lung cancer research[1].

Product Specifications

CAS Number

[2490291-68-2]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-26.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC=C1C2=NC3=CC(C)=CC=C3N2)/C=C/C4=CC=CC=C4OCC

Molecular Formula

C25H23N3O2

Molecular Weight

397.47

References & Citations

[1]Kavitha Donthiboina, et al. Synthesis and biological evaluation of substituted N- (2- (1H-benzo[d]imidazol-2-yl) phenyl) cinnamides as tubulin polymerization inhibitors. Bioorg Chem. 2020 Oct;103:104191.