Antitumor agent-70

Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].

Product Specifications

CAS Number

[2454133-88-9]

UNSPSC

12352005

Target

Apoptosis; c-Kit

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-70.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CN=C1)N/N=C/C2=CC=C(C(NC3=CC=C(C)C=C3)=O)C=C2

Molecular Formula

C21H18N4O2

Molecular Weight

358.39

References & Citations

[1]Xin-Yang Li, et al. Design, synthesis and biological evaluation of novel (E) -N-phenyl-4- (pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM) . Bioorg Chem. 2020 Oct;103:104189.