ATX inhibitor 22

ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) with IC50 of 218 nM but lost its inhibitory activity of LPAR1[1].

Product Specifications

CAS Number

[2969213-59-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atx-inhibitor-22.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(N(C1CCOCC1)C2=C(C=C(C(C(NC3=CC(F)=C(C(F)=C3)Cl)=O)=C2)Cl)Cl)=O

Molecular Formula

C19H17Cl3F2N2O4S

Molecular Weight

513.77

References & Citations

[1]Souvik Banerjee, et al. Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors. Bioorg Chem. 2020 Oct; 103: 104188.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Autotaxin

Curated Selection

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