ATX inhibitor 22
ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) with IC50 of 218 nM but lost its inhibitory activity of LPAR1[1].
Product Specifications
CAS Number
[2969213-59-8]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atx-inhibitor-22.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(N(C1CCOCC1)C2=C(C=C(C(C(NC3=CC(F)=C(C(F)=C3)Cl)=O)=C2)Cl)Cl)=O
Molecular Formula
C19H17Cl3F2N2O4S
Molecular Weight
513.77
References & Citations
[1]Souvik Banerjee, et al. Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors. Bioorg Chem. 2020 Oct; 103: 104188.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
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