Tubulin polymerization-IN-25

Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1].

Product Specifications

CAS Number

[2490538-46-8]

UNSPSC

12352005

Target

Farnesyl Transferase; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-25.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC(C(C2=CC=C3NC4=C(C=CC=C4)SC3=C2)=O)=C5C=C(OC)C=CN15)=O

Molecular Formula

C24H18N2O3S

Molecular Weight

414.48

References & Citations

[1]Iuliana-Monica Moise, et al. Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity. Bioorg Chem. 2020 Oct; 103: 104184.