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PRMT5-IN-19

PRMT5-IN-19 (Compound 41) is an selective orally active non-nucleoside PRMT5 inhibitor with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay) . PRMT5-IN-19 can occupy the SAM-binding pocket in PRMT5 and block methyltransferase activity, which displays good selectivity over other PRMTs and PKMTs. PRMT5-IN-19 inhibits cell proliferation by inducing cell apoptosis, and can be used for cancer-related research[1].

Product Specifications

CAS Number

2783961-86-2

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt5-in-19.html

Solubility

10 mM in DMSO

Smiles

C[C@H](OC1=CC=C(C2=CC3=C(N=CN=C3N2)C4=CCNCC4)C=C1)C5=CC=CC=C5

Molecular Formula

C25H24N4O

Molecular Weight

396.48

References & Citations

[1]Deqin Rong, et al. Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5. J Med Chem. 2022 Jun 9;65 (11) :7854-7875.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT1; PRMT4; PRMT5

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