SLF1081851 (TFA)

SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM) . SLF1081851 (TFA) plays a key role in development and immune system[1][2].

Product Specifications

CAS Number

[2763730-98-7]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/slf1081851-tfa.html

Solubility

10 mM in DMSO

Smiles

NCCCC1=NC(C2=CC=C(CCCCCCCCCC)C=C2)=NO1.O=C(O)C(F)(F)F

Molecular Formula

C23H34F3N3O3

Molecular Weight

457.53

References & Citations

[1]Fritzemeier R, et al. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2022 Jun 9;65 (11) :7656-7681. |[2]Lynch Kevin R, et al. Preparation of oxadiazoles as inhibitors of spinster homolog 2 (SPNS2) for use in therapy: World Intellectual Property Organization, WO2022056042[P]. 2022-03-17.