PARP1-IN-10
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) [1].
Product Specifications
CAS Number
2494001-21-5
UNSPSC
12352005
Target
Apoptosis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(C(N(C)C(N1C)=O)=O)=C\C2=CC=C(C=C2)OCC(N3CCCCC3)=O
Molecular Formula
C20H23N3O5
Molecular Weight
385.41
References & Citations
[1]Essam Eldin A. Osman, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Aug; 104: 104198.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
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