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Topoisomerase I/II inhibitor 4

Selected Variant

HY-149002

Size: 1 Each

Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research[1].

Product Specifications

CAS Number

3031403-77-4

UNSPSC

12352005

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-i-ii-inhibitor-4.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(C3=C1C4=C(C=CC=C4)N3CC5=CN([C@H]6O[C@@H]([C@H](C6)O)CO)N=N5)=O)C7=C([N+]([O-])=C2)C=CC=C7

Molecular Formula

C27H21N5O6

Molecular Weight

511.49

References & Citations

[1]Yang X, et al. Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity. J Med Chem. 2022 Jun 9;65 (11) :8040-8061.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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