PI3Kα-IN-7

PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor. PI3Kα-IN-7 also inhibits PI3Kβ. PI3Kα-IN-7 decreases cancer cells mitochondrial membrane potential and induces apoptosis[1].

Product Specifications

CAS Number

[2417098-53-2]

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kα-in-7.html

Solubility

10 mM in DMSO

Smiles

C1(NCC2=CC(N=C(N3CCOCC3)N=C4N5CCOCC5)=C4S2)=NNC=N1

Molecular Formula

C17H22N8O2S

Molecular Weight

402.47

References & Citations

[1]Ye T, et al. Design, synthesis and biological evaluation of novel 2,4-bismorpholinothieno[3,2-d]pyrimidine and 2-morpholinothieno[3,2-d]pyrimidinone derivatives as potent antitumor agents. Bioorg Chem. 2020 Jun;99:103796.