Fosdevirine

Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572) -resistant clinical isolates[1].

Product Specifications

CAS Number

[1018450-26-4]

Product Name Alternative

GSK2248761; FDV

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fosdevirine.html

Purity

98.96

Solubility

10 mM in DMSO

Smiles

CO[P@@](C1=C(C(N)=O)NC2=CC=C(Cl)C=C12)(C3=CC(/C=C/C#N)=CC(C)=C3)=O

Molecular Formula

C20H17ClN3O3P

Molecular Weight

413.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Castellino S, et al. Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity. Chem Res Toxicol. 2013 Feb 18;26 (2) :241-51.