Cavα2δ1&NET-IN-2
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) . Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].
Product Specifications
CAS Number
2143586-17-6
UNSPSC
12352005
Target
Calcium Channel; Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cavα2δ1-net-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCN(C2=NC(N)=NC=C21)C)C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3
Molecular Formula
C22H26N6O2S
Molecular Weight
438.55
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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