Rovunaptabin
Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
Product Specifications
CAS Number
145563-68-4
Product Name Alternative
ARC 183; BC 007
UNSPSC
12352208
Target
Thrombin
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rovunaptabin.html
Purity
98.96
Solubility
10 mM in H2O
Smiles
DNA,d(G-G-T-T-G-G-T-G-T-G-G-T-T-G-G)
References & Citations
[1]Bompiani KM, Monroe DM, Church FC, Sullenger BA. A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. J Thromb Haemost. 2012;10 (5) :870-880. |[2]Bonifacio L, Church FC, Jarstfer MB. Effect of locked-nucleic acid on a biologically active g-quadruplex. A structure-activity relationship of the thrombin aptamer. Int J Mol Sci. 2008;9 (3) :422-433.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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